Title: Genetic Signatures of Exceptional Longevity in Humans
Article Snip: "...Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians (median age at death 104 years) and 914 genetically matched healthy controls. Using these data, we built a genetic model that includes...and our findings suggest that different variants of these genes may have a protective role. The most intriguing examples are LMNA and WRN: while specific variants of these two genes determine progeria and accelerated aging, alternative variants may increase life span. "
Reference: nih.gov
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