Genetic Signatures of Exceptional Longevity in Humans

Title: Genetic Signatures of Exceptional Longevity in Humans

Article Snip: "...Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians (median age at death 104 years) and 914 genetically matched healthy controls. Using these data, we built a genetic model that includes...and our findings suggest that different variants of these genes may have a protective role. The most intriguing examples are LMNA and WRN: while specific variants of these two genes determine progeria and accelerated aging, alternative variants may increase life span. "

Reference: nih.gov

Is longevity determined by genetics?

Title: Is longevity determined by genetics?

Article Snip: "The duration of human life (longevity) is influenced by genetics, the environment, and lifestyle. ...Now people in the United States live about 80 years on average, but some individuals survive for much longer. Scientists are studying people in their nineties (called nonagenarians) and hundreds (called centenarians, including semi-supercentenarians of ages 105-109 years and supercentenarians, ages 110+) to determine what contributes to their long lives. They have found...The study of longevity genes is a developing science. It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood. A few of the common variations (called polymorphisms) associated with long life spans are found in the APOE, FOXO3, and CETP genes"

Reference: medlineplus.gov